Dinitrofluorobenzene → N-(3-(2-Thiazolyl)phenyl)-2,4-dinitroaniline

https://huagongshe.com/reaction/581955

Participants

Role	Name	HCID	Charge
Reactant	Dinitrofluorobenzene	HCID 6264	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3-(1,3-Thiazol-2-yl)aniline	HCID 11019390	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	N-(3-(2-Thiazolyl)phenyl)-2,4-dinitroaniline	HCID 54468810	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

A mixture of 2,4-dinitrofluorobenzene (1.14 ml, 9.1 mmol), 2t from Example 2 (1.6 g, 9.1 mmol) and potassium carbonate (1.51 g, 10.9 mmol) in dry N-methyl-2-pyrrolidone (10 ml) is heated to 80° C. for 2 hours. The cooled mixture is poured into ice-water. The precipitate is filtered off, washed with water and dried to yield: 3.05 g (98%). Mp 1 97-203° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05922724
Source dataset	uspto-grants-1999_07
ORD ID	ord-fefc9efd0c094949b05eb83ee7e028b7
Source note	uspto-grants-1999_07