Formic Acid → HCID 11324445, compound

HRID 581975Notes

Reaction equation

HRID 581975 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[CH:13]=2)=[C:8]([CH:10]=1)[NH2:9])(=[O:3])[CH3:2].[OH-].[Na+].[CH:26](O)=O>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:11]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]4[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=4)[CH:13]=3)[CH:26]=[N:9][C:8]=2[CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 11358577HCID 11358577, compound

Product 1

HCID 11324445HCID 11324445, compound

Procedure

5-acetyl-2-(3-(3-pyridyl)phenylamino)aniline (5 g, 16.5 mmol) in formic acid (50 ml) is stirred at 90° C. for 1.5 hours. The cooled reaction mixture is made alkaline by addition of 12 M NaOH. 5-acetyl-1-(3-(3-pyridyl)phenyl)benzimidazole is filtered off washed with water and dried. Quantitative yield. m.p. 195-97° C.

Workup

  1. customThe cooled reaction mixture
  2. filtration5-acetyl-1-(3-(3-pyridyl)phenyl)benzimidazole is filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-ed169a8857424ac4bdebcb1c485eacbb
Source dataset
uspto-grants-1999_07
Patent number
US05922724

Reaction notes

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