Water → HCID 54142092, compound

Participants

Reaction Steps

5-(5-Isoxazolyl)-1-(3-(4-pyrimidinyl)phenyl)benzimidazole (45a) was prepared as follows: 5-(3-dimethylamino-1-oxo-2-propen-1-yl)-1-(3-(4-pyrimidinyl)phenyl)benzimidazole: (44b) (314 mg) was reacted with DMF-dimethylacetal (1.5 ml) under argon in DMF (3 ml) at 120° C. for 5 hours. After cooling to the mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with brine, dried, and concentrated under reduced pressure. The residue was purified by column-chromatography on silica gel using a mixture of CH2Cl2 and methanol (30:1) as the eluent to give 5-(3-dimethylamino-1-oxo-2-propen-1-yl)-1-(3-(4pyrimidinyl)phenyl)benzimidazole (320 mg, 87%).

Provenance & Evidence