HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (5-Chloro-6-quinolinyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Ethyl 5-chloroquinoline-6-carboxylate | HCID 53760849 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (5-Chloro-6-quinolinyl)methanol | HCID 45588508 | 95.1% |
Reaction Steps
Lithiumaluminiumhydride (1.66 g) was added portionwise to a solution of intermediate 1 (10.11 g) in tetrahydrofuran (325 ml) at 0° C. under N2 and the mixture was stirred for 1 hour. Ethylacetate (70 ml) and water (3 ml) were added to the mixture which was subsequently filtered. The filtrate was dried over MgSO4, filtered and evaporated, yielding 7.9 g (93%) 5-chloro-6-quinolinemethanol (intermediate 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922734 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-7292cfb81c8f4c59bcfa6106ace7341f |
| Source note | uspto-grants-1999_07 |