Thionyl Chloride → HCID 70221442, compound

Participants

Reaction Steps

Thionyl chloride (8 ml) was added dropwise to a solution of intermediate 5 (8 g) in CH2Cl2 (400 ml) at 0° C. and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was partitioned between CH2Cl2 and water which was alkalized with a saturated K2CO3 solution. The separated organic layer was dried over MgSO4, filtered and the filtrate evaporated, yielding 8.4 g (100%) (±)-5-chloro-6-[chloro[3-(trifluoromethyl) phenyl]methyl]quinoline (intermediate 6).

Provenance & Evidence