1H-1,2,4-Triazole → HCID 49824866, compound

Participants

Reaction Steps

A mixture of intermediate 30 (0.846 g), 1,2,4-triazole (0.346 g) and potassium carbonate (0.7 g) in CH3CN (30 ml) was stirred and refluxed for 2 hours. The solvent was evaporated and the residue was taken up in water and extracted with CH2Cl2. The organic layer was dried MgSO4, filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH/NH4OH 98/2/0.1) and the solvent of the desired fraction was evaporated, yielding 0.25 g (27%) of (±)-6-[1H-1,2,4-triazol-1-yl[3-(trifluoromethyl)phenyl]methyl]-2(1H)-quinolinone (compound 3).

Provenance & Evidence