Sodium Hydroxide → HCID 70222249, compound

Participants

Reaction Steps

A mixture of compound 3 (7.3 g) and NaOH (4.12 g) in water (20 ml) was stirred at room temperature for 15 minutes. Hydroxylamine-O-sulfonic acid (6.3 g) was added portionwise and the mixture was stirred for 12 hours. The precipitate was filtered off and crystallyzed from 2-propanol, yielding 2.3 g (±)-(1-amino-6-[1H-1,2,4-triazol-1-yl-[3-(trifluoromethyl)phenyl]methyl]-2(1H)-quinolinone (compound 20; mp. 222.3° C.).

Provenance & Evidence