HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 582043Generated: October 31, 2026
HCID 10663122, compound → 2-(5-Bromo-2-pyridinyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one
https://huagongshe.com/reaction/582043
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 10663122 | HCID 10663122 | — |
| Reactant | 5-Bromo-2-(trimethylstannyl)pyridine | HCID 11151376 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(5-Bromo-2-pyridinyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1-one | HCID 15407932 | — |
Reaction Steps
A mixture of 2-bromo-3-(4-(methylsulfonyl)-phenyl)-2-cyclopenten-1-one (700 mg, 2.2 mmol), Pd2 (dba)3 (170 mg, 0.18 mmol), and the total sample of 2-trimethylstannanyl-5-bromopyridine from Step 1 was dissolved in NMP (10 mL) and degassed. The resulting solution was heated to 100° C. for 3.5 h then cooled. The mixture was diluted with EtOAc, washed 2 times with 10% NH4OH and brine, dried over MgSO4, and concentrated. The residue was purified by flash chromatography (70% EtOAc/hexanes) followed by an EtOAc/Et2O swish to provide 110 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05922742 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-ae7f81f0023f4e638dbc4d0a6b259ceb |
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| Source note | uspto-grants-1999_07 |
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