HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (1-methyl-1H-benzimidazol-2-yl)(piperidin-4-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | (1-methyl-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine | HCID 12891475 | — |
| Solvent | Water | HCID 962 | — |
| Product | (1-methyl-1H-benzimidazol-2-yl)(piperidin-4-yl)amine | HCID 22009124 | — |
Reaction Steps
Combine (1-methyl-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (0.42 g, 1.4 mmol) and 48% hydrobromic acid (25 mL). Heat to reflux. After 3 hours, cool, add water and a solution of potassium hydroxide (5 g) in water (50 mL). Extract twice with dichloromethane. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922737 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-89bd0536dfff42728dd7a988a94d5a99 |
| Source note | uspto-grants-1999_07 |