Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

HRID 582087Notes

Reaction equation

HRID 582087 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][O:7]C1CCCCO1.[Br-].[Mg+2].[Br-]>C(OCC)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][OH:7]

Participants

4

Reactant 2

HCID 82241Magnesium BromideHCID 184646842-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether

Product 1

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluorethyl ether.

Workup

  1. extractionextract with water
  2. dry with materialDry the organic layer over Na2SO4
  3. filtrationfilter
  4. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-26ef0ac7709c42318885ec71ce3a82b9
Source dataset
uspto-grants-1999_07
Patent number
US05922737

Reaction notes

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