Water → 2-Oxazolidinone, 5-(phenylmethyl)-

HRID 582119ノート

反応式

HRID 582119 の反応式
[O:1]1[CH2:10][CH:2]1[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[O-][C:12]#[N:13].[K+].[OH2:15]>CN(C=O)C>[CH2:3]([CH:2]1[O:1][C:10](=[O:15])[NH:13][CH2:12]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 962WaterHCID 948262-(Phenylmethyl)oxiraneHCID 11378442Potassium cyanate

生成物 1

HCID 30392712-Oxazolidinone, 5-(phenylmethyl)-収率 36%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2,3-Epoxypropylbenzene (60 g, 448 mmol) and potassium cyanate (70 g, 364 mmol) were refluxed in DMF (600 ml) and water (300 ml) for 4 hours. The solvent was evaporated in vacuo and water added. The aqueous was then extracted with ethyl acetate, dried (Mg SO4) and evaporated. Recrystallization from ethyl acetate gave the product (28.2 g, 36%) Mpt 106-107° C. MS (EI) 177 (M+), 133, 86.

後処理

  1. customThe solvent was evaporated in vacuo and water
  2. additionadded
  3. extractionThe aqueous was then extracted with ethyl acetate
  4. dry with materialdried (Mg SO4)
  5. customevaporated
  6. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-1a8354829ef54617bdf80643835b4d6e
出典データセット
uspto-grants-1999_07
特許番号
US05922748

反応ノート

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