HCID 178447792, compound → HCID 178447793, compound

Participants

Reaction Steps

Diisopropyl E-1-fluoro-3(1-trityl-1,2,4-triazol-3-yl)prop-2-ene phosphonate (0.62 g, prepared as described in Example 19), was hydrogenated in dry isopropanol (10 ml) over 10% palladium on carbon (0.20 g) over a period of five days. The solution was filtered through Hyflo Super-Cel and evaporated under reduced pressure. The residue was chromatographed on silica, using ethyl acetate then ethyl acetate-ethanol (9:1) as eluant, to give diisopropyl 1-fluoro-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate (0.24 g) as a colourless gum. NMR (CDCl3): δ 1.3(12H,m), 2.3(2H,m), 3.0(2H,m), 4.7(2H,m and 1H,m), 7.05-7.4(15H,m), 7.85(1H,s). The structure was confirmed by 13C and 31P NMR. M/S: MH+ 536. Other fractions gave detritylated material (0.18 g), also as a clear gum.

Provenance & Evidence