反应详情

To a stirred solution of 2-(1-chloroethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (3.16 g, 14.2 mmol) in methylene chloride (30 mL) was added drop-wise bromine (0.804 mL, 15.6 mmol) in methylene chloride (7 mL). The reaction mixture was stirred at room temperature for 2 h. The product precipitated out and was collected by filtration (2.42 g, 56.6%). LCMS calculated for C11H11BrClN2O (M+H)+: m/z=301.0. Found: 301.1.

1. customThe product precipitated out
2. filtrationwas collected by filtration (2.42 g, 56.6%)