反应详情

A solution of the product of step (1) (0.9g) in methanol (150 ml) was hydrogenated at room-temperature and pressure using 10% palladium on carbon (0.9 g) catalyst. After the uptake of hydrogen was complete, the catalyst was filtered off and the solvent evaporated. The residue was crystallised from ethanol, and gave 7-amino-2-(2-furyl)-5-[2-(hydroxyphenyl)ethyl]amino-[1,2,4]triazolo[1,5-a][1,3,5]triazine, m.p. 260°-263° C. microanalysis, found: C, 57.2; H, 4.8; N, 28.6%; C16H15N7O2 (0.15) C2H5OH requires: C, 57.0; H, 4.7; N, 28.5%; NMR: 2.81 (t, 2H, phenyl-H), 3.49 (m, 2H, CH2N); 6.71 (d of d, 1H, furyl-4H), 7.03 (d, 1H, furyl-3H), 6.7-7.15 (complex, 4H, phenyl-H); 7.85 (m, 1H, NH); 7.84 (s, 1H, furyl-5H); 8.09 (br s, 2H, NH2) and 9.31 (s, 1H, OH); m/e 338 (M+H)+.

1. filtrationthe catalyst was filtered off
2. customthe solvent evaporated
3. customThe residue was crystallised from ethanol