Propionyl chloride → HCID 11107609, compound

HRID 582216Notes

Reaction equation

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH2:15].[C:16](Cl)(=[O:19])[CH2:17][CH3:18]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH:15][C:16](=[O:19])[CH2:17][CH3:18]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 70189091187872-62-4

Product 1

HCID 11107609HCID 11107609, compound

Procedure

Using (E)-2-(6-methoxyindan-1-ylidene)ethylamine, the procedure of Reference Example 14 was otherwise repeated to provide 2-(5-methoxy-1H-inden-3-yl)ethylamine hydrochloride. Then, starting with this 2-(5-methoxy-1H-inden-3-yl)ethylamine hydrochloride and propionyl chloride, the title compound was synthesized in otherwise the same manner as Example 8 (yield 86%).

Sources & evidence

ORD record: ord-67f06c75743049d0afb5fd8b3c991f6e
Source dataset: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05922771

Reaction notes

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