2,6-Diisopropylphenyl isocyanate → 1-(2,6-Diisopropylphenyl)-3-(3-hydroxy-4-methoxybenzyl)urea

HRID 582221Notes

Reaction equation

HRID 582221 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH2:5][NH2:6].[CH:12]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:23])[CH3:22])[C:16]=1[N:24]=[C:25]=[O:26])([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH:12]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:22])[CH3:23])[C:16]=1[NH:24][C:25]([NH:6][CH2:5][C:4]1[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:2]([OH:1])[CH:3]=1)=[O:26])([CH3:13])[CH3:14]

Participants

4

Reactant 2

HCID 922592,6-Diisopropylphenyl isocyanateHCID 11329985-(Aminomethyl)-2-methoxyphenol

Product 1

HCID 154086551-(2,6-Diisopropylphenyl)-3-(3-hydroxy-4-methoxybenzyl)urea

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Added to 40 ml of toluene were 600 mg (3.92 mmol) of 3-hydroxy-4-methoxybenzylamine and 810 mg (3.90 mmol) of 2,6-diisopropylphenyl isocyanate, and the mixture was stirred under reflux for 8 hours.

Workup

  1. temperatureunder reflux for 8 hours

Sources & evidence

ORD record
ord-9e9f8b5be59f43e48b6c506e926727ba
Source dataset
uspto-grants-1999_07
Patent number
US05922767

Reaction notes

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