2-(Ethylamino)ethanol → HCID 53934067, compound

HRID 582301Notes

Reaction equation

HRID 582301 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=3)=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2].[CH2:27]([NH:29][CH2:30][CH2:31][OH:32])[CH3:28]>>[CH2:27]([N:29]([CH2:30][CH2:31][OH:32])[C:22]([C:21]1[CH:20]=[CH:19][C:18]([C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:5]3[C:4]([NH:3][CH2:1][CH3:2])=[CH:9][CH:8]=[CH:7][N:6]=3)[CH2:11][CH2:12]2)=[O:17])=[CH:26][CH:25]=1)=[O:24])[CH3:28]

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 53906916HCID 53906916, compound

Product 1

HCID 53934067HCID 53934067, compoundYield 72%

Procedure

By the same procedure as described in the example 1, synthesis was carried out starting with 4-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid and using 2-(ethylamino)ethanol. Then, the product was recrystallized using ethyl acetate and hexane to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 1, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-3dac1bd60add4cd099cc4785d743216b
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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