1-(2-Hydroxyethyl)piperazine → HCID 9826462, compound

HRID 582305Notes

Reaction equation

HRID 582305 reaction equation
[CH:1]([NH:4][C:5]1[C:6]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:27]=[CH:26][C:22]([C:23]([OH:25])=O)=[CH:21][CH:20]=3)=[O:18])[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[OH:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[OH:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][N:34]([C:23](=[O:25])[C:22]2[CH:21]=[CH:20][C:19]([C:17]([N:14]3[CH2:15][CH2:16][N:11]([C:6]4[C:5]([NH:4][CH:1]([CH3:2])[CH3:3])=[CH:10][CH:9]=[CH:8][N:7]=4)[CH2:12][CH2:13]3)=[O:18])=[CH:27][CH:26]=2)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 109595584-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid

Product 1

HCID 9826462HCID 9826462, compoundYield 82%

Procedure

By the same procedure as described in the example 19, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid and using 1-(2-hydroxyethyl)piperazine. Then, the product was recrystallized using isopropanol and ether to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 19, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-c7cccd7b9cdb4bbbbd7f30054f6f359f
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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