1-(2-Hydroxyethyl)piperazine → HCID 54333275, compound

HRID 582308Notes

Reaction equation

HRID 582308 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=3)=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2].[OH:27][CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH2:1]([NH:3][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[CH:20][C:21]([C:22]([N:33]4[CH2:34][CH2:35][N:30]([CH2:29][CH2:28][OH:27])[CH2:31][CH2:32]4)=[O:23])=[CH:25][CH:26]=3)=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 53906916HCID 53906916, compound

Product 1

HCID 54333275HCID 54333275, compoundYield 76%

Procedure

By the same procedure as described in the example 19, synthesis was carried out starting with 4-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid and using 1-(2-hydroxyethyl)piperazine. Then, the product was recrystallized using ethyl acetate and hexane to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 19, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-514b64c9e560454faf4373f53e0287ef
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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