L-Valinol → HCID 86754238, compound

HRID 582311Notes

Reaction equation

HRID 582311 reaction equation
[CH:1]([NH:4][C:5]1[C:6]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=3)=[O:18])[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[NH2:28][C@@H:29]([CH:32]([CH3:34])[CH3:33])[CH2:30][OH:31]>>[OH:31][CH2:30][C@@H:29]([NH:28][C:23]([C:22]1[CH:21]=[CH:20][C:19]([C:17]([N:14]2[CH2:13][CH2:12][N:11]([C:6]3[C:5]([NH:4][CH:1]([CH3:2])[CH3:3])=[CH:10][CH:9]=[CH:8][N:7]=3)[CH2:16][CH2:15]2)=[O:18])=[CH:27][CH:26]=1)=[O:24])[CH:32]([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 640993L-ValinolHCID 109595584-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid

Product 1

HCID 86754238HCID 86754238, compoundYield 80%

Procedure

By the same procedure as described in the example 30, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid and using (S)-(+)-2-amino-3-methyl-1-butanol. Then, the product was recrystallized using ethanol and isopropyl ether to give a desired compound.

Workup

  1. customBy the same procedure as described in the example 30, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-abb31305ef074acea39421229466e36c
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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