2-Amino-1-butanol, (+)- → 1-[N-[(1S)-1-Ethyl-2-hydroxyethyl]carbamoyl]-4-[1-[3-(isopropylamino)-2-pyridyl] piperazin-4-yl-carbonyl]benzene

Participants

Reaction Steps

By the same procedure as described in the example 31, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin4-yl-carbonyl]benzoic acid methyl ester and using (S)-(+)-2-amino-1-butanol. Then, the product was recrystallized using acetonitrile and isopropyl ether to give the desired compound.

Provenance & Evidence