Serinol → HCID 54554307, compound

HRID 582315Notes

Reaction equation

HRID 582315 reaction equation
CO[C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:6][CH:5]=1.[NH2:29][CH:30]([CH2:33][OH:34])[CH2:31][OH:32]>>[OH:32][CH2:31][CH:30]([CH2:33][OH:34])[NH:29][C:3]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:13][CH2:14][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:26])[CH3:27])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:16][CH2:17]2)=[O:11])=[CH:6][CH:5]=1)=[O:28]

Participants

3

Reactant 2

HCID 68294SerinolHCID 53711670HCID 53711670, compound

Product 1

HCID 54554307HCID 54554307, compoundYield 79%

Procedure

By the same procedure as described in the example 31, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]benzoic acid methyl ester and using 2-amino-1,3-propanediol. Then, the product was recrystallized using ethyl acetate and ether to give the desired compound.

Workup

  1. customBy the same procedure as described in the example 31, synthesis
  2. customThen, the product was recrystallized

Sources & evidence

ORD record
ord-1fe34ac332f4482aa9a98bcf0a92532a
Source dataset
uspto-grants-1999_07
Patent number
US05922871

Reaction notes

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