反应详情

A mixture of ethyl 6-chloro-2-methoxybenzoate (1.8 g, 8.4 mmol), bromine (1.41 g, 8.8 mmol) and acetic acid (5 ml) is stirred at room temperature for 24 hours. The reaction mixture is poured into water and extracted with ethyl acetate. The organic phase is separated and concentrated and the residue is purified by column chromatography (petrol ether: ethyl acetate, 95:5 v/v) yielding the pure product as a yellow oil, 1.7 g, (69.%).

1. extractionextracted with ethyl acetate
2. customThe organic phase is separated
3. concentrationconcentrated
4. customthe residue is purified by column chromatography (petrol ether: ethyl acetate, 95:5 v/v)