HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 10929564, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 10926377 | HCID 10926377 | — |
| Reactant | Carbamic acid, N-(4,6-dimethoxy-2-pyrimidinyl)-, phenyl ester | HCID 10945667 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 10929564 | HCID 10929564 | — |
Reaction Steps
0.56 ml (3.7 mmol) of DBU is added dropwise to a suspension of 1.33 g (3.7 mmol) of 5-(N-methyl-N-methanesulfonylaminomethyl)-2-methanesulfonylbenzenesulfonamide and 1.03 g (3.7 mmol) of phenyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate in 20 ml of acetonitrile. After 2 h, the mixture is diluted with water and diethyl ether and acidified to pH 1-2 with HCl and the precipitated product is filtered off, washed with water and diethyl ether and dried; yield: 1.78 g (89.5%) of N-(4,6-dimethoxypyrimidin-2-ylaminocarbonyl)-5-(N-methyl-N-methanesulfonylamiinomethyl)-2-methanesulfonylbenzenesulfonamide of melting point 205-210° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05925596 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-5ded4d1407ef46e892b8ea8fca31e1b3 |
| Source note | uspto-grants-1999_07 |