Hydrochloric Acid → (1S,3S)-N1,N1-dimethylcyclopentane-1,3-diamine dihydrochloride

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Reaction Steps

(1S-trans)-[3-(N,N-Dimethylamino)cyclopentyl]carbamic acid 1,1-dimethylethyl ester (0.537 g, 2.35 mmol) in 1,4-dioxan (4 ml) was treated with a saturated solution of hydrogen chloride in 1,4-dioxan (15 ml) and additional 1,4-dioxan (8 ml). After 50 minutes at 21° C., another portion of a saturated solution of hydrogen chloride in 1,4-dioxan (5 ml) was added, and after a further 2.5h, the opaque solution was concentrated by evaporation to give the title compound as a beige solid, which was used without characterisation.

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