Trifluoroacetic acid → HCID 54080646, compound

Participants

Reaction Steps

In the same way as that described in Example 8, Step 4 using 1-[2-benzyloxy-1-(4-fluorophenyl)ethyl]-4-(tert-butyloxycarbonyl)piperazine (1.58 g, 3.8 mmol), trifluoroacetic acid (5 mL) and CH2Cl2 (50 mL). The piperazine (1.11 g, 92%) was isolated as a colourless oil. 1H NMR (250 MHz, CDCl3) δ2.36-2.57 (4H, m), 2.84-2.89 (4H, m), 3.49-3.54 (1H, m), 3.65 (1H, dd, J=9.9 and 5.4 Hz), 3.79 (1H, dd, J=9.9 and 5.8 Hz), 4.47 (2H, s), 6.99 (1H, dd, JHA-HB =8.7 Hz and JHA-F =8.7 Hz), 7.20-7.35 (7H, m). MS (ES+) (315, M+1).

Provenance & Evidence