Diethyl Ether → (1S)-1-Methyl-2-nitroxyethylamine hydrochloride

Participants

Reaction Steps

In 80 ml of 4N hydrochloric acid-dioxane were dissolved 4.52 g of (1S)-N-(t-butoxycarbonyl)-1-methyl-2-nitroxyethylamine, and the mixture was left to stand at room temperature for 1 hour and 50 minutes. To the mixture were added 160 ml of ether, and the crystals were collected by filtration and dried to obtain 3.02 g of the desired compound as colorless crystals.

Provenance & Evidence