HCID 86754259, compound → HCID 86754258, compound

Participants

Reaction Steps

5.7 g of ethyl 2-amino-6-methyl-4-(3-nitrophenyl)-5-[1-oxo-11-(4,4-diphenyl-1-piperidinyl)undecyl]pyridine-3-carboxylate hydrochloride and 150 ml of triethyl orthoacetate are heated at 125° C. for 72 h with passage of nitrogen. The solution is concentrated in vacuo, and the residue is dried and then chromatographed through a silica gel column using petroleum ether/ethyl acetate/triethylamine 7:3:0.5 as eluent. The pure fractions are combined and concentrated, and the residue is dried in a high vacuum. 3 g of the title compound are obtained as a pale yellow oil.

Provenance & Evidence