Ethylenediamine → N-BOC-ethylenediamine

Participants

Reaction Steps

To a stirred solution of 1,2-diaminoethane 2-3 (50 g, 832 mmol) and CH2Cl2 (500 ml) was added a solution of BOC2O (45 g, 208 mmole) in CH2Cl2 (100 ml) dropwise over a 3 h period. After 20 h, the reaction was filtered and then the filtrate was concentrated at 60° C. to furnish amine 2-4 as a colorless oil.

Provenance & Evidence