HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromide ion → Methyl isoindoline-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromide ion | HCID 259 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | [1(R) Methyl-2-(pyridin-2-yl)ethyl]carbamic acid trifluoroacetate | HCID 86754265 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl isoindoline-5-carboxylate | HCID 19828496 | — |
Reaction Steps
A toluene solution (20 mL) of 7-4 (181 mg, 0.48 mmol), 2-5 (171 mg, 0.60 mmol) and Et3N (266 μl, 1.9 mmol) was refluxed for 3 h and then concentrated to dryness. The residue was purified by flash chromatography (silica, 3:2 CH2Cl2 /acetone) to provide 7-5 as a colorless gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05925655 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-e6c91ffca3d442c29f884fd1052fe7ec |
| Source note | uspto-grants-1999_07 |