4-Nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid → 4-Amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid

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Reaction Steps

4-Nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid is described in Chem. Pharm. Bull., 1984, 32, 3968. The hydrogenation of 1.48 g of this nitro derivative is performed in methanol in the presence of Raney® nickel. After 4 hours with stirring, the catalyst is filtered off, the mixture is evaporated to dryness and the residue is taken up with ether and filtered off to obtain 1 g of the expected product. m.p.=180° C. (dec.).

Provenance & Evidence