Dichloromethane → HCID 131721313, compound

HRID 582788Notes

Reaction equation

HRID 582788 reaction equation
C(Cl)Cl.[CH3:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:7]=1[C:14]1[N:18]([C:19]2[CH:24]=[CH:23][C:22]([C:25](=[O:34])[N:26]([CH3:33])[CH2:27][CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])=[CH:21][C:20]=2[CH:35]([CH3:37])[CH3:36])[N:17]=[C:16]([C:38]([NH:40][C:41]2([C:51]([OH:53])=[O:52])[CH:48]3[CH2:49][CH:44]4[CH2:45][CH:46]([CH2:50][CH:42]2[CH2:43]4)[CH2:47]3)=[O:39])[CH:15]=1.[OH-].[OH:55][CH2:56][CH2:57][N+:58]([CH3:61])([CH3:60])[CH3:59]>CO>[OH:55][CH2:56][CH2:57][N+:58]([CH3:61])([CH3:60])[CH3:59].[CH3:13][O:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH3:4])[C:7]=1[C:14]1[N:18]([C:19]2[CH:24]=[CH:23][C:22]([C:25](=[O:34])[N:26]([CH3:33])[CH2:27][CH2:28][CH2:29][N:30]([CH3:31])[CH3:32])=[CH:21][C:20]=2[CH:35]([CH3:37])[CH3:36])[N:17]=[C:16]([C:38]([NH:40][C:41]2([C:51]([O-:53])=[O:52])[CH:42]3[CH2:43][CH:44]4[CH2:45][CH:46]([CH2:47][CH:48]2[CH2:49]4)[CH2:50]3)=[O:39])[CH:15]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 31255Choline, hydroxideHCID 5311451SR142948A

Product 1

HCID 131721313HCID 131721313, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
35 °C

Procedure

A solution of 1 ml of DCM containing 0.05 g of the compound obtained in EXAMPLE 1' and 0.025 ml of a 45% solution of choline hydroxide in MeOH are left stirring for 15 minutes at 35° C. and the mixture is then concentrated under vacuum. The residue is triturated in 5 ml of ether and the precipitate formed is drained. 0.03 g of the expected product is obtained, m.p.=150° C.

Workup

  1. concentrationthe mixture is then concentrated under vacuum
  2. customThe residue is triturated in 5 ml of ether
  3. customthe precipitate formed

Sources & evidence

ORD record
ord-c31c6ae8620c495dad5ad94a370d4d93
Source dataset
uspto-grants-1999_07
Patent number
US05925661

Reaction notes

Loading…