HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isethionic Acid → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid isethionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isethionic Acid | HCID 7866 | — |
| Reactant | SR142948A | HCID 5311451 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid isethionate | HCID 86754287 | 46.5% |
Reaction Steps
A mixture of 0.1 g of the compound obtained in EXAMPLE 1' in 3 ml of 2-propanol is heated to reflux, 0.022 g of 83% isethionic acid (obtained by elution of sodium isethionate on DOWEX® 50 W×8 resin in H+ form) is added and crystallization is allowed to take place overnight. The crystallized product formed is drained. 0.055 g of the expected product is obtained, m.p.=230° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05925661 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-0315a2a4f4e44e0691efe2780235ac73 |
| Source note | uspto-grants-1999_07 |