Sodium Hydroxide → 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt

HRID 582801Notes

Reaction equation

HRID 582801 reaction equation
[Na+:1].C([N:4]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]([O-:19])=[O:18])[CH2:12][CH2:11][N:10]([CH2:20][C:21]([O-:23])=[O:22])[CH2:9][CH2:8][N:7]([CH2:24][C:25]([O-:27])=[O:26])[CH2:6][CH2:5]1)=O.[Na+].[Na+].[OH-].[Na+]>>[Na+:1].[N:7]1([CH2:24][C:25]([O-:27])=[O:26])[CH2:6][CH2:5][NH:4][CH2:15][CH2:14][N:13]([CH2:16][C:17]([O-:19])=[O:18])[CH2:12][CH2:11][N:10]([CH2:20][C:21]([O-:23])=[O:22])[CH2:9][CH2:8]1.[Na+:1].[Na+:1]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 1542900210-Formyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt

Product 1

HCID 108625271,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt

Conditions

Temperature
70 °C

Procedure

The mixture from step B) is then added with 77.3 kg of 30% w/w NaOH and heated to 70° C. for 9 h. The resulting aqueous solution contains 0.131 kmol of the desired compound (content determined by HPLC), as a trisodium salt.

Sources & evidence

ORD record
ord-215b299d168b45829c2a24132bc99d2a
Source dataset
uspto-grants-1999_07
Patent number
US05925753

Reaction notes

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