Pyrrolidine, 1-(2-(4-(2,2-dimethyl-7-methoxy-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)ethyl)- → HCID 10895762, compound

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Reaction Conditions

Reaction Steps

7-Methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3-chromene (1 kg) was dissolved in acetic acid (10 l) by heating to 60° C. Palladium on carbon (10%, 50% wet, 100 g) was added and the mixture hydrogenated at 60° C., 2-3 atmospheres hydrogen pressure for 24 hours. The mixture was cooled down to 40-50° C. and the catalyst filtered off. The filtrate was evaporated in vacuum to an oil. It was dissolved in 2-propanol (4 l) and sodium hydroxide was added (ca. 1.2 l, 36%) in order to adjust the pH of the mixture to 10-11. The solution was seeded at 40-50° C. The mixture was cooled down to ca. 5° C. and the product filtered off and washed with water (3 l) and dried at 50° C. Yield 0.9 kg, 95%.

Provenance & Evidence