Acrylonitrile → HCID 11032218, compound

HRID 582827Notes

Reaction equation

HRID 582827 reaction equation
[CH3:1][NH:2][CH2:3][C@@H:4]([C@H:6]([C@@H:8]([C@@H:10]([CH2:12][OH:13])[OH:11])[OH:9])[OH:7])[OH:5].[C:14](#[N:17])[CH:15]=[CH2:16]>CO>[CH3:1][N:2]([CH2:16][CH2:15][C:14]#[N:17])[CH2:3][C@@H:4]([C@H:6]([C@@H:8]([C@@H:10]([CH2:12][OH:13])[OH:11])[OH:9])[OH:7])[OH:5]

Participants

4

Reactant 2

HCID 7855AcrylonitrileHCID 8567N-Methyl-D-glucamine

Product 1

HCID 11032218HCID 11032218, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
63 °C

Procedure

607 g (3.1 mol) of N-methylglucamine (NMG) are suspended in 729 g of methanol in a 2 l four-necked flask with a stirrer, dropping funnel, reflux condenser and thermometer. The reaction mixture is heated to 63° C., while stirring. 163 g (3.1 mol) of acrylonitrile are added dropwise in the course of 30 minutes. When the addition has ended, the clear solution is stirred at 63° C. for a further 3 hours. According to analysis by gas chromatography, the conversion in the reaction is complete, so that the reaction product can be employed directly for the hydrogenation (second process stage).

Workup

  1. temperaturereflux condenser
  2. additionWhen the addition
  3. stirringthe clear solution is stirred at 63° C. for a further 3 hours

Sources & evidence

ORD record
ord-ecb8b216deed424dbc37a81ddfc91cc6
Source dataset
uspto-grants-1999_07
Patent number
US05925775

Reaction notes

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