Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Methoxy-2-[[(1-methylethylidene)amino]oxy]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Acetone, oxime | HCID 67180 | — |
| 반응물 | 4-Methoxy-2-nitrobenzonitrile | HCID 288665 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Methoxy-2-[[(1-methylethylidene)amino]oxy]benzonitrile | HCID 18796445 | 87.2% |
반응 단계
In 20 ml of DMF was dissolved acetone oxime (0.74 g), followed by sodium hydride (0.30 g). After this mixture had stirred for 30 minutes, 4-methoxy-2-nitro-benzonitrile (1.50 g) was added. After an additional 30 minutes the reaction was poured into water (500 ml) and filtered. The solid was collected and dissolved in DCM (250 ml), dried (MgSO4), and concentrated in vacuo. The resulting solid was recrystallized from ethanol to yield 1.5 g of 4-methoxy-2-[[(1-methylethylidene)-amino]oxy]benzonitrile, m.p. 78-79° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05925766 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-21a87d10fe224d3e99ec92abe84da1bb |
| 출처 메모 | uspto-grants-1999_07 |