Dimethylcarbamoyl Chloride → HCID 54443352, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-[1-(4-pyridyl)piperazinyl]-1,2-benzisoxazol-6-ol (0.80 g) in pyridine (10 ml) was added dimethylcarbamyl chloride (0.70 g) under N2. The reaction was heated to 85° C. for 2 hours. TLC (silica gel 30% MeOH/CH2Cl2) showed no starting material was present. The solvent was removed in vacuo and the residue was flash chromatographed (silica gel) eluting with 7% MeOH/CH2Cl2 to afford 0.80 g of material. The material was further purified through recrystallization from CH2Cl2 /pet. ether to afford 0.70 g of the product, m.p. 171-172° C.

Provenance & Evidence