HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 582885Generated: October 30, 2026
Piperazine → 7-Bromo-6-methoxy-3-(1-piperazinyl)-1,2-benzisoxazole hydrochloride
https://huagongshe.com/reaction/582885
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 7-Bromo-3-chloro-6-methoxy-1,2-benzisoxazole | HCID 18796450 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-Bromo-6-methoxy-3-(1-piperazinyl)-1,2-benzisoxazole hydrochloride | HCID 18796448 | — |
Reaction Steps
To a sealed tube was added 7-bromo-3-chloro-6-methoxy-1,2-benzisoxazole (2.0 g) and piperazine (2.6 g). The reaction was heated to 140° C. over 30 minutes and then cooled to room temperature. The residue was dissolved in MeOH and concentrated in vacuo. Flash column chromatography (silica gel) eluting with 30% MeOH/EtOAc provided a residue upon evaporation (1.0 g) which was recrystallized from MeOH/CH2Cl2 /pet. ether to yield 1.0 g, m.p. 268-269° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05925766 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-34c93ea7a5b347b2922fc4709b742496 |
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| Source note | uspto-grants-1999_07 |
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