Dichloromethane → HCID 54438084, compound

Participants

Reaction Steps

In a 500 ml Hastelloy-made autoclave having been purged with nitrogen were put 100 g (0.426 mol) of the methyl 2-chloro-3-oxodecanoate (VII) prepared in (1) above, 5 ml of a methylene chloride solution of 780 mg (0.426 mmol) of a ruthenium-optically active phosphine complex Ru2Cl4 [(+)-Tol-BINAP]2NEt3, and 300 ml of methanol, and the mixture was allowed to react at 50° C. under a hydrogen pressure of 30 atm for 18 hours. Methanol was removed by evaporation to yield 95.78 g (0.405 mol; yield: 95.0%) of the title compound.

Provenance & Evidence