HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Methyl 2-chloro-3-oxopentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Methyl 3-oxovalerate | HCID 121699 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-chloro-3-oxopentanoate | HCID 545096 | 100% |
Reaction Steps
A solution of 104 g (0.8 mol) of methyl 3-oxopentanoate (available from Wacker Chemical) in 500 ml of toluene was cooled to 0 to 5° C., and 108 g (0.8 mol) of sulfuryl chloride was added thereto dropwise, followed by stirring at room temperature overnight. Toluene was removed by evaporation to give 131.6 g (0.8 mol; yield: 100%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05925792 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-ce6cc85c8fe24531bb5ad656f02fac70 |
| Source note | uspto-grants-1999_07 |