Dichloromethane → HCID 54420244, compound

Participants

Reaction Steps

In a 100 ml Hastelloy-made autoclave having been purged with nitrogen were put 10 g (0.0607 mol) of the methyl 2-chloro-3-oxopentanoate prepared in (1) above, 0.2 ml of a methylene chloride solution of 26 mg (0.144 mmol) of a ruthenium-optically active phosphine complex Ru2Cl4 [(+)-Tol-BINAP]2NEt3, and 30 ml of methanol, and the mixture was allowed to react at 50° C. under a hydrogen pressure of 30 atm for 18 hours. Methanol was removed by evaporation to give 9.61 g (0.0577 mol; yield: 95.0%) of the title compound. Optical rotation [α]D25 =+6.35° (c=0.976, CHCl3)

Provenance & Evidence