2-(4-Hydroxyphenyl)-5-octylpyrimidine → HCID 21225362, compound

HRID 582962Notes

Reaction equation

HRID 582962 reaction equation
[CH2:1]([C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[N:13][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[F:22][C:23]([F:64])([C:60]([F:63])([F:62])[F:61])[C:24]([F:59])([F:58])[C:25]([F:57])([F:56])[O:26][C:27]([F:55])([F:54])[C:28]([F:53])([F:52])[O:29][C:30]([F:51])([F:50])[C:31]([F:49])([F:48])[C:32]([F:47])([F:46])[C:33]([F:45])([F:44])[C:34]([F:43])([F:42])[CH2:35][O:36][CH2:37][CH2:38][CH2:39][CH2:40]Br>>[CH2:1]([C:9]1[CH:14]=[N:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:40][CH2:39][CH2:38][CH2:37][O:36][CH2:35][C:34]([F:42])([F:43])[C:33]([F:44])([F:45])[C:32]([F:46])([F:47])[C:31]([F:48])([F:49])[C:30]([O:29][C:28]([F:52])([F:53])[C:27]([F:54])([F:55])[O:26][C:25]([F:56])([F:57])[C:24]([F:58])([F:59])[C:23]([F:64])([F:22])[C:60]([F:61])([F:63])[F:62])([F:51])[F:50])=[CH:17][CH:16]=2)=[N:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 6040552-(4-Hydroxyphenyl)-5-octylpyrimidineHCID 21225277HCID 21225277, compound

Product 1

HCID 21225362HCID 21225362, compound

Procedure

The title compound was prepared essentially as in Example 1 by combining 5-octyl-2-(4-hydroxyphenyl)pyrimidine (1.01 g, 3.56 mmol) and 4-(6-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2,3,3,4,4,5,5,6,6-decafluorohexyloxy)-1-bromobutane (3.07 g, 4.0 mmol; prepared by combining 1,4-dibromobutane and 2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2,3,3,4,4,5,5,6,6-decafluorohexanol). The resulting crude product was isolated and further purified essentially as described in Example 3, eluting with 15 volume percent ethyl acetate/hexane, to yield 2.3 g of purified product.

Workup

  1. customThe resulting crude product was isolated

Sources & evidence

ORD record
ord-909b0de58a37443a91bb62af5b9833ee
Source dataset
uspto-grants-1999_07
Patent number
US05928562

Reaction notes

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