2-Bromoethyl ethyl ether → 5-(2-(Ethoxy)ethoxy)-2-[4-(3-(2-(2-(nonafluorobutoxy) tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy)phenyl]pyrimidine

Participants

Reaction Steps

The title compound was prepared essentially as in Example 1 by combining 5-hydroxy-2-[4-(3-(2-(2-(nonafluorobutoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy)phenyl]pyrimidine (1.0 g, 1.51 mmol,) and 2-bromoethyl ethyl ether (0.58 g, 3.79 mmol). The resulting crude product was isolated and further purified essentially as described in Example 3, eluting with 30 volume percent ethyl acetate/hexane, to yield 0.76 g of purified product.

Provenance & Evidence