4-(2-(2-(Pentafluoroethoxy) tetrafluoroethoxy)-2,2-difluoroethoxy)-1-bromobutane → 5-Hexyloxy-2-[4-(4-(2-(2-(pentafluoroethoxy) tetrafluoroethoxy)-2,2-difluoroethoxy)butoxy)phenyl]pyrimidine

Participants

Reaction Steps

The title compound was prepared essentially as in Example 1 by combining 4-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)-1-bromobutane (14.9 g, 32.0 mmol, Example 19) with 5-hexyloxy-2-(4-hydroxyphenyl)pyrimidine (8.0 g, 29.4 mmol). The resulting product was isolated by addition of water (160 mL), followed by filtration and recrystallization from ethanol. The recrystallized precipitate was dried at about 130° C., and the resulting product was further purified by distillation using a Kugelrohr apparatus (b.p. 190-205° C. at 0.3 torr; yield of 15.2 g).

Provenance & Evidence