HCID 21225329, compound → HCID 86754303, compound
Reaction equation
[F:1][C:2]([F:25])([C:21]([F:24])([F:23])[F:22])[C:3]([F:20])([F:19])[C:4]([F:18])([F:17])[O:5][C:6]([F:16])([F:15])[CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]Br.[CH2:26]([C:35]1[CH:36]=[N:37][C:38]([C:41]2[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=2)=[N:39][CH:40]=1)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[CH2:26]([C:35]1[CH:36]=[N:37][C:38]([C:41]2[CH:42]=[CH:43][C:44]([O:47][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][CH2:7][C:6]([O:5][C:4]([F:18])([F:17])[C:3]([F:20])([F:19])[C:2]([F:25])([F:1])[C:21]([F:24])([F:23])[F:22])([F:16])[F:15])=[CH:45][CH:46]=2)=[N:39][CH:40]=1)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]Participants
3
Procedure
The title compound was prepared essentially as in Example 1 by combining 5-(2-(nonafluorobutoxy)-2,2-difluoroethoxy)-pentyl bromide (6.9 g of 91% purity, 13.5 mmol, Example 33) with 5-nonyl-2-(4-hydroxyphenyl)pyrimidine (4.0 g, 13.5 mmol). The resulting crude product was isolated essentially as described in Example 3 and purified by chromatography on silica gel, eluting with 5 vol. % ethyl acetate in hexane, recrystallization from ethanol followed by Kugelrohr distillation (240° C. at 0.4 torr) to provide a yield of 5.6 g.
Sources & evidence
- ORD record
- ord-c3c7d38630c64f89a25159cdbb627747
- Source dataset
- uspto-grants-1999_07
- Patent number
- US05928562
Reaction notes
Loading…