2-(2-(2-(Pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)ethyl methane sulfonate → 5-Octyloxy-2-[4-(2-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)ethoxy)phenyl]pyrimidine

Participants

Reaction Steps

The title compound was prepared essentially as in Example 1 by combining 2-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)ethyl methane sulfonate (4.54 g, 10 mmol, prepared from 2-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)ethanol and methanesulfonyl chloride) with 5-octyloxy-2-(4-hydroxyphenyl)pyrimidine (3.0 g, 10 mmol). The resulting crude product was purified by recrystallization from ethanol followed by Kugelrohr distillation (230° C. at 0.3 torr) to provide a yield of 6.5 g.

Provenance & Evidence