HCID 21225370, compound → HCID 21225387, compound

HRID 582993Notes

Reaction equation

HRID 582993 reaction equation
[F:1][C:2]([F:27])([F:26])[O:3][C:4]([F:25])([F:24])[C:5]([F:23])([F:22])[O:6][C:7]([F:21])([F:20])[C:8]([F:19])([F:18])[C:9]([F:17])([F:16])[CH2:10][O:11][CH2:12][CH2:13][CH2:14]Cl.[CH2:28]([C:37]1[CH:38]=[N:39][C:40]([C:43]2[CH:48]=[CH:47][C:46]([OH:49])=[CH:45][CH:44]=2)=[N:41][CH:42]=1)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]>>[CH2:28]([C:37]1[CH:38]=[N:39][C:40]([C:43]2[CH:44]=[CH:45][C:46]([O:49][CH2:14][CH2:13][CH2:12][O:11][CH2:10][C:9]([F:17])([F:16])[C:8]([F:19])([F:18])[C:7]([O:6][C:5]([F:23])([F:22])[C:4]([F:25])([F:24])[O:3][C:2]([F:27])([F:26])[F:1])([F:21])[F:20])=[CH:47][CH:48]=2)=[N:41][CH:42]=1)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]

Participants

3

Reactant 2

HCID 21225370HCID 21225370, compoundHCID 1358247454-(5-Nonyl-2-pyrimidinyl)phenol

Product 1

HCID 21225387HCID 21225387, compound

Procedure

The title compound was prepared essentially as in Example 1 by combining 3-(4-(2-(trifluoromethoxy)tetrafluoroethoxy)-2,2,3,3,4,4-hexafluorobutoxy)propyl chloride (6.7 g, 14.6 mmol, prepared from 1,3-dicloropropane and 4-(2-(trifluoromethoxy)tetrafluoroethoxy)-2,2,3,3,4,4-hexafluorobutanol) with 5-nonyl-2-(4-hydroxyphenyl)pyrimidine (4.32 g, 14.6 mmol). The resulting crude product was purified by recrystallization from ethanol, Kugelrohr distillation, followed by chromatography on silica, eluting with hexane/ethyl acetate (10 vol. % ethyl acetate) to provide a yield of 4.3 g.

Workup

  1. distillationThe resulting crude product was purified by recrystallization from ethanol, Kugelrohr distillation
  2. washeluting with hexane/ethyl acetate (10 vol. % ethyl acetate)
  3. customto provide a yield of 4.3 g

Sources & evidence

ORD record
ord-e3d12d072c7e4545815c4032e370b4c6
Source dataset
uspto-grants-1999_07
Patent number
US05928562

Reaction notes

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