HCID 21225322, compound → HCID 21225414, compound

Participants

Reaction Steps

The title compound was prepared essentially as in Example 1 by combining 5-octyloxy-2-[4-hydroxy-2,3-difluorophenyl]pyrimidine (1.5 g, 4.7 mmol) with 3-(4-(nonafluorobutoxy)-2,2,3,3,4,4-hexafluorobutoxy)propyl bromide (2.45 g, 5.1 mmol, prepared from 1,3-dibromopropane and 4-(nonafluorobutoxy)-2,2,3,3,4,4-hexafluorobutanol). The reaction mixture was quenched with water, and the resulting crude product was further purified by recrystallization from ethanol, followed by Kugelrohr distillation (210° C. at 0.5 torr), to provide a yield of 2.6 g.

Provenance & Evidence