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In a three necked flask equipped with a dropping funnel, a thermometer and reflux condenser, n-hexadecanethiol (165 g) was dissolved in acetonitrile (1000 ml) in a nitrogen atmosphere. To the solution, p-nitrophenyl isocyanate (100 g) was gradually added, stirred at room temperature for 10 minutes, and then heat-refluxed for 30 minutes. The reaction liquid was cooled to room temperature to allow crystals to precipitate. The crystals were collected by filtering and washed with acetonitrile, to obtain S-n-hexadecyl p-nitrophenylthiocarbamate (250 g) at a yield of 97%.

1. customIn a three necked flask equipped with a dropping funnel
2. temperaturea thermometer and reflux condenser
3. temperatureheat-refluxed for 30 minutes
4. customThe reaction liquid
5. temperaturewas cooled to room temperature
6. customto precipitate
7. customThe crystals were collected
8. filtrationby filtering
9. washwashed with acetonitrile